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# Iso2Mesh: An Image-based 3D Surface and Volumetric Mesh Generator

|                |                          |
|----------------|------------------------- |
| **Author**     | Qianqian Fang            |
| **E-mail**     | <q.fang at neu.edu>      |
| **Department** | Bioengineering           |
| **Institute**  | Northeastern University  |
| **Address**    | 360 Huntington Ave, Boston, MA 02115 |
| **Version**    | 1.9.6 (Lion's Head)      |
| **License**    | GPL v2 or later (see COPYING) (this license does not cover the binaries under the bin/ directory, see Section III for more details) |
| **URL**        | http://iso2mesh.sf.net   |


## Table of Contents

- [Introduction](#introduction)
- [Iso2Mesh Suite](#iso2mesh-suite)
- [Overview of functions](#overview-of-functions)
- [Compiling Iso2mesh](#compiling-iso2mesh)
- [Acknowledgement](#acknowledgement)

#### Introduction

"Iso2Mesh" is a MATLAB/Octave-based mesh generation toolbox,
designed for easy creation of high quality surface and 
tetrahedral meshes from 3D volumetric images. It contains 
over 200 mesh processing scripts/programs, working 
either independently or interacting with external free 
meshing utilities. Iso2Mesh toolbox can directly convert
a 3D image stack, including binary, segmented or gray-scale 
images such as MRI or CT scans, into quality volumetric 
meshes. This makes it particularly suitable for multi-modality 
medical imaging data analysis and multi-physics modeling.
Above all, iso2mesh is open-source. You can download it for 
free. You are also allowed to extend the toolbox for your
own research and share with other users. Iso2Mesh is 
cross-platform and is compatible with both MATLAB and GNU Octave 
(a free MATLAB clone).

The details of this toolbox can be found in the following
papers (citing the first paper is highly encouraged):

- Anh Phong Tran, Shijie Yan and Qianqian Fang*, (2020) "Improving 
 model-based fNIRS analysis using mesh-based anatomical and 
 light-transport models," Neurophotonics, 7(1), 015008
- Qianqian Fang and David Boas, "Tetrahedral mesh generation from 
 volumetric binary and gray-scale images," Proceedings of IEEE 
 International Symposium on Biomedical Imaging (ISBI 2009), 
 pp. 1142-1145, 2009

The first paper published recently describes a fully automated high-quality
[brain mesh generation pipeline](http://mcx.space/brain2mesh) 
built upon Iso2Mesh, providing a showcase for nearly all core
functionalities provided in this toolbox.

#### Iso2Mesh Suite

In addition to convenient 3D mesh generation functionalities,
the development of Iso2Mesh has also resulted in a number of 
submodules that have also received wide adoption - some 
are even more popular than Iso2Mesh itself. For example:

- JSONLab (http://openjdata.org/jsonlab): a JSON/UBJSON/MassagePack 
 encoder and decoder [(Editor Pick-of-the-week, Popular File 2018)](https://www.mathworks.com/matlabcentral/fileexchange/33381-jsonlab-a-toolbox-to-encode-decode-json-files)
- Brain2Mesh (http://mcx.space/brain2mesh): a fully automated
 high-quality brain mesh generation toolbox built on Iso2Mesh
- JNIfTI (http://github.com/fangq/jnifti): a fast and portable 
 NIfTI-1/2 reader/writer and next-gen NIfTI file format
- Metch (http://iso2mesh.sf.net/metch): a 3D mesh registration toolbox
- JData specification (http://openjdata.org): a highly portable
 easy-to-use scientific data annotation method and specification
- ZMat (http://github.com/fangq/zmat): a data compression library 
 and MATLAB/Octave toolbox

Currently, Iso2Mesh and its submodules are broadly distributed 
among popular open-source MATLAB toolboxes, especially among major 
neuroimaging tools, including

- Fieldtrip (http://www.fieldtriptoolbox.org) [[iso2mesh/jsonlab](https://github.com/fieldtrip/fieldtrip/tree/master/external/iso2mesh)]
- BrainStorm (https://neuroimage.usc.edu/brainstorm) [[iso2mesh/brain2mesh/easyh5](https://neuroimage.usc.edu/brainstorm/Tutorials/FemMesh#Mesh_tools)]
- Lead-DBS (http://www.lead-dbs.org) [[iso2mesh](https://github.com/netstim/leaddbs/tree/master/ext_libs/iso2mesh)]
- ROAST (https://www.parralab.org/roast) [[iso2mesh](https://github.com/andypotatohy/roast/tree/master/lib/iso2mesh)]
- HOMER2 (https://github.com/BUNPC/AtlasViewer) [[iso2mesh/metch](https://github.com/BUNPC/AtlasViewer/tree/master/iso2mesh)]
- REST (https://github.com/goodshawn12/REST) [[iso2mesh](https://github.com/goodshawn12/REST/tree/master/dependencies/iso2mesh)]

#### Overview of functions

Creation of high-quality surface and tetrahedral meshes 
from volumetric images has been a challenging task. 
There are very limited software and resources available 
for this purpose. Commercial tools, such as Mimics 
and Simpleware, are both expensive and limited in flexibility. 
Iso2Mesh was developed as a free alternative to these 
expensive commercial tools and provides researchers a highly
flexible, modular and streamlined image-based mesh 
generation pipeline. Intuitive interfaces and rich
functionalities allow one to enjoy a wide range 
of mesh-based analyses, ranging from 3D volumetric 
image pre-processing (hole-filling, thinning and 
thickening), surface mesh modeling (extraction, 
remeshing, repairing, and smoothing) to volumetric 
mesh creation.

Converting 3D image stacks into quality surface and
tetrahedral meshes is one of the core features of iso2mesh.
We provide serveral automated functions to perform
the image->mesh and mesh->image conversion, including

- `vol2mesh` (`v2m`): convert a 3D volumetric image into a tetrahedral mesh
- `vol2surf` (`v2s`): extract triangular surfaces from a 3D image volume
- `surf2mesh` (`s2m`): create a tetrahedral mesh from a triangular surface mesh
- `surf2vol` (`s2v`): rasterize a close-surface to a volumetric image
- `mesh2vol` (`m2v`): rasterize a tetrahedral mesh to a volumetric image

Most of these function are associated with several meshing
options and parameters to give users full control to mesh 
density, adaptivity, region labeling and mesh quality.
The output data for some of these functions can be used
as the input for the others, giving endless combinations to
analyze your data. In addition to image-based mesh generation,
iso2mesh can also mesh geometry primitives such as spheres,
cubes and cylinders. This makes iso2mesh a CAD-capable software,
fully integrated in the MATLAB/Octave environments.

Another core feature of iso2mesh is surface mesh
processing. A surface mesh is the bridge between a voxelated
image and a tetrahedral mesh, and is the foundation for 
successful 3D mesh generation. In iso2mesh, we provide the
following key functions for surface mesh processing:

- `smoothsurf` (`sms`): smoothing a surface mesh
- `surfboolean`: boolean operations (join, intersect, diff) of two surfaces
- `meshresample`: downsample a surface mesh to a coarse surface
- `meshrefine`: refine a surface mesh
- `remeshsurf`: remesh a surface mesh, including up-sampling and down-sampling
- `meshcheckrepair`: test a surface mesh and remove defects and self-intersecting elements

A third area iso2mesh excels is the rich set of mesh analysis 
and inquiry functions. For both surface and tetrahedral meshes, 
iso2mesh can report the element volume (or area), mesh quality
metrics, node connectivity and neighbors, interior edges and 
boundaries, surface norms, element centroids, etc.

Last, but not the least, iso2mesh can import and export mesh
data from/to a dozen of file formats, including those used by the 
popular FEA software like COMSOL and ABAQUS. The STL format can
export an iso2mesh-generated mesh for 3D printing.
Users can not only export the data to a file, but also make
3D plots in MATLAB/Octave using the powerful "plotmesh" function.

These examples are only a small fraction in the over 200 optimized 
functions provided by iso2mesh. The modular design of iso2mesh 
makes the code easy to understand and easy to be intergrated in 
your data analysis workflow. Please check out the full iso2mesh 
function list and detailed help information in the following URL:

http://iso2mesh.sf.net/cgi-bin/index.cgi?Doc/FunctionList

#### Compiling Iso2Mesh

The default release of Iso2Mesh packages already contains pre-compiled
binaries for a wide range of platforms (32/64bit Windows, 32/64bit Linux
and Mac with 64bit Intel and 32 bit PowerPC CPUs). So, without needing 
to recompile, Iso2Mesh can be executed out-of-box on MATLAB or GNU Octave.

However, in the event that your operating system is not supported, or
due to license restrictions, such as creating a release for various
Linux distributions, you can recreate the mesh utility binaries under
`iso2mesh/bin` folder using the source codes provided under `iso2mesh/tools`
by following the below commands:

 ```
git clone --recurse-submodules https://github.com/fangq/iso2mesh.git
cd iso2mesh
rm -rf bin/*.mex* bin/*.exe
cd tools
make clean
make
```

This will download and recompile the below binaries in the bin folder:

- cgalmesh
- cgalsurf
- cgalsimp2
- jmeshlib
- meshfix
- tetgen1.5
- cork

Once these binary files are recreated, you can run all the major functionalities
of Iso2Mesh. The gtrefine utility is depreciated and replaced by 
cork and tetgen.

To compile the above external tools, the below tools must be pre-installed
(tested on Ubuntu 14.04 LTS, if you use another Linux distribution, the package
names might be different)

- gcc
- cmake
- libcgal-dev
- libsuitesparse-dev
- zlib1g-dev

you can install these on Ubuntu by running:
 ```
 sudo apt-get install gcc cmake libcgal-dev libsuitesparse-dev zlib1g-dev
 ```
 on Ubuntu or Debian. If you use Fedora, you need to install the below packages
```
 sudo dnf install cmake CGAL-devel SuperLU-devel blas-static gcc-c++ zlib-devel octave-devel
```

#### Acknowledgement

This toolbox interacts with a number external meshing tools 
to perform the essential functionalities. These tools are listed 
below:

> bin/tetgen and bin/tetgen1.5:

- Summary: tetgen is a compact and fast 3D mesh generator
- License: GNU Affero General Public License version 3
- URL: http://tetgen.org/
- Author: Hang Si <si at wias-berlin.de>
- Research Group: Numerical Mathematics and Scientific Computing
::Weierstrass Institute for Applied Analysis and Stochastics
::Mohrenstr. 39, 10117 Berlin, Germany

> bin/cgalsurf:

- Summary: cgalsurf is a utility to extract a surface mesh from a gray-scale or a binary 3D image
- Source: it is a slightly modified version from Surface_mesher example from CGAL 3.4
- License: CGAL v3 core library is licensed under QPL (Q Public License) other modules are under the Lesser General Public License (LGPL)
- URL: http://www.cgal.org/Manual/3.3/doc_html/cgal_manual/Surface_mesher/Chapter_main.html

> bin/cgalmesh and bin/cgalpoly:

- Summary: cgalmesh and cgalpoly are utilities to produce surface and volumetric meshes from a multi-valued volumetric image
- Source: it is a slightly modified version from Mesh_3 example from CGAL 3.5
- License: CGAL v3 core library is licensed under QPL (Q Public License) other modules are under the Lesser General Public License (LGPL)
- URL: http://www.cgal.org/Manual/3.5/doc_html/cgal_manual/Mesh_3/Chapter_main.html

> bin/cgalsimp2:

- Summary: cgalsimp2 performs surface mesh simplification in iso2mesh.
- Source: it is adapted from Surface_mesh_simplification example of CGAL library
- License: CGAL v3 core library is licensed under QPL (Q Public License) other modules are under the Lesser General Public License (LGPL)
- URL: http://www.cgal.org/Manual/3.4/doc_html/cgal_manual/Surface_mesh_simplification/Chapter_main.html

> bin/jmeshlib:

- Summary: meshfix is adapted from the sample code of JMeshLib
- License: GPL (GNU General Public License) v2 or later
- URL:http://jmeshlib.sourceforge.net/
- Author:Marco Attene <attene at ge.imati.cnr.it>
::Istituto di Matematica Applicata e Tecnologie Informatiche
::Consiglio Nazionale delle Ricerche
::Via De Marini, 6 (Torre di Francia)
::16149 Genoa - ITALY 

> bin/meshfix:

- Summary: meshfix is a mesh-repairing utility
- License: GPL (GNU General Public License) v2 or later
- URL:http://code.google.com/p/meshfix/
- Author: Marco Attene, Mirko Windhoff and Axel Thielscher.
::Istituto di Matematica Applicata e Tecnologie Informatiche
::Consiglio Nazionale delle Ricerche
::Via De Marini, 6 (Torre di Francia)
::16149 Genoa - ITALY 

> bin/cork:

- Summary: A robust surface mesh Boolean operation algorithm
- License: LGPL (GNU Lesser General Public License)
- URL:https://github.com/gilbo/cork
- Author: Gilbert Bernstein

> bin/gtsrefine:

- Summary: GTS is the GNU Triangulated Surface Library
- License: LGPL (GNU Lesser General Public License)
- URL:http://gts.sourceforge.net/
- Author: GTS developers


**Note:** Iso2Mesh and the above meshing utilities are considered 
as an "aggregate" rather than "derived work", based on the 
definitions in GPL FAQ (http://www.gnu.org/licenses/gpl-faq.html#MereAggregation)
Therefore, the license of Iso2Mesh and these utilities are independent.
The Iso2Mesh license only applies to the scripts and documentation/data
in this package and exclude those programs stored in the bin/ directory.
The source codes of the modified meshing utilities are available
separately at Iso2Mesh's website and retain their upstream licenses.

Your acknowledgement of Iso2Mesh in your publications or 
presentations would be greatly appreciated by the author of 
this toolbox. The citation information can be found in the
Introduction section.